Requirement for Fc effector function is overcome by binding potency for broadly reactive anti-alphavirus antibodies
Victoria Callahan, Matthew S. Sutton, Christina L. Gardner, Jessica Prado-Smith, Doreswamy Kenchegowda, Megan M. Dunagan, Mrunal Gosavi, A. Karim Embong, Courtney Green, Hannah Kamphaugh, Tammy Y. Chen, Daniel Long, Jodi L. Vogel, Ivan Košík, Jonathan Wilson Yewdell, , Julie M. Fox
This study identifies antibody avidity as a correlate for in vivo efficacy of broadly reactive anti-alphavirus antibodies and links it to Fc-dependent mechanisms.
Science Translational Medicine · Aug 20, 2025Peer-reviewedMicrobiology