Marcin Domagala

This study develops an in vitro 3D tumor spheroid model to target pro-tumoral macrophages with antibodies, showing effective killing even in spheroid centers.

The paper uses time-series RNA-Seq and gene regulatory network inference to study how CLL cells respond to immune signals in vitro, revealing dynamic regulatory mechanisms and patient-specific gene modules.

This study shows CLL cells acquire FOLR2 from nurse-like cells via trogocytosis, enhancing their survival and proliferation in vitro.

The paper develops an agent-based model to simulate monocyte differentiation into nurse-like cells in chronic lymphocytic leukemia and identifies patient-specific macrophage phenotypes linked to cancer survival.

The paper builds a Boolean model to simulate macrophage polarization in an in-vitro chronic lymphocytic leukaemia model, revealing the formation of tumour-associated macrophages.