Hyojin Park

Gene-specific endothelial programs drive AVM pathogenesis in SMAD4 and ALK1 loss-of-function

This study identifies gene-specific mechanisms of AVM formation in endothelial cells with SMAD4 or ALK1 loss-of-function, showing distinct molecular and cellular pathways leading to different vascular malformations.

PIEZO1 overexpression in hereditary hemorrhagic telangiectasia arteriovenous malformations

The paper identifies PIEZO1 overexpression in HHT2 AVMs and shows that inhibiting PIEZO1 reduces AVM formation in Alk1-deficient mice.

Latrophilin-2 Orchestrates Endothelial Flow-Mediated Smad1/5 Activation via Endoglin and Shank3

This paper identifies Latrophilin-2 as a mediator of flow-induced Smad1/5 activation in endothelial cells through interactions with Endoglin and Shank3, independent of G-proteins.