Sarah K. Buddenborg

TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMPZQ variants

TRPtracker aggregates TRPMPZQ variants and their PZQ sensitivity data to monitor resistance and support schistosomiasis control strategies.

Optimisation of single-nuclei isolation and RNA sequencing of parasitic nematodes

This paper optimizes single-nuclei isolation and RNA sequencing for parasitic nematodes, improving yield and RNA quality across life stages and sexes.

Extensive transmission and variation in a functional receptor for praziquantel resistance in endemic Schistosoma mansoni

The paper uses population genomics and functional genetics to identify praziquantel resistance variants in Schistosoma mansoni.

The stage- and sex-specific transcriptome of the human parasite Schistosoma mansoni

This study provides a comprehensive transcriptomic analysis of Schistosoma mansoni across eight life stages, revealing sex-specific gene expression patterns and developmental transitions.

Daily rhythms in the transcriptomes of the human parasite Schistosoma mansoni

This study identifies daily transcriptomic rhythms in Schistosoma mansoni, revealing rhythmic gene expression patterns and their potential relevance to parasite survival and drug targets.

Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system

The paper assembles the chromosomes of Schistosoma mansoni, revealing insights into the evolution of its ZW sex-determination system through gene annotation and synteny analysis.

Complete representation of a tapeworm genome reveals chromosomes capped by centromeres, necessitating a dual role in segregation and protection

The paper presents the complete genome of Hymenolepis microstoma, revealing chromosome structures capped by centromeres that serve both segregation and protection roles.

Transcriptional responses of Biomphalaria pfeifferi and Schistosoma mansoni following exposure to niclosamide, with evidence for a synergistic effect on snails following exposure to both stressors

This study examines the transcriptomic responses of Biomphalaria pfeifferi and Schistosoma mansoni to niclosamide exposure, revealing differential gene expression patterns in snails and sporocysts under various stress conditions.

The in vivo transcriptome of Schistosoma mansoni in two prominent vector species, Biomphalaria pfeifferi and B. glabrata

This study characterizes the in vivo transcriptome of Schistosoma mansoni in two Biomphalaria snail species, revealing gene expression patterns during intramolluscan development and host interactions.