Prophage and metabolic determinants of Staphylococcus aureus survival to vancomycin identified via TraDIS screening
Sophia Zborowsky, Urszula Łapińska, Paul O'Neill, Audrey Farbos, Aaron R. Jeffries, Xiaoliang Ba, Mark A. Holmes, Maisem Laabei, Bing Zhang, Mark A. T. Blaskovich, Andrew J. Grant, Stefano Pagliara
This study identifies 52 genes in MRSA associated with reduced vancomycin survival, emphasizing the role of prophage loci, metabolism, and stress responses over discrete resistance mechanisms.
mSystems · Sep 16, 2026Peer-reviewedMicrobiology