Mark A. T. Blaskovich

Disruption of cAMP Signalling and RNA Regulation Confers Cefiderocol Resistance in Acinetobacter baumannii

This study identifies two mechanisms of cefiderocol resistance in Acinetobacter baumannii: cAMP signalling disruption and Hfq RNA-binding domain truncation, both linked to iron homeostasis and reduced drug activity.

Cellular heterogeneity in the response of Burkholderia thailandensis to antibiotics and phages in synthetic spatial refuges

This study investigates how Burkholderia thailandensis responds to antibiotics and phages in spatial refuges, revealing distinct subpopulation behaviors and interactions.

Prophage and metabolic determinants of Staphylococcus aureus survival to vancomycin identified via TraDIS screening

This study identifies 52 genes in MRSA associated with reduced vancomycin survival, emphasizing the role of prophage loci, metabolism, and stress responses over discrete resistance mechanisms.

Optimisation of Solid-Phase Antimicrobial Susceptibility Testing for Hydrophobic Antibiotics Using an Agarose-Based MIC Assay

The paper develops an agarose-based MIC assay to improve the accuracy of antimicrobial susceptibility testing for hydrophobic antibiotics.

New glucose-abstaining Chlorella algae doubles mammalian cell culture longevity, boosts performance and drops serum needs enabling scaled applications.

Competition with Pseudomonas aeruginosa induces Staphylococcus aureus in an antibiotic-tolerant viable but non culturable state

This study shows that S. aureus enters a viable but non-culturable state when competing with P. aeruginosa, altering its metabolism and survival strategies in response to antibiotics.

Characterisation of in vitro resistance selection against second-/last-line antibiotics in methicillin-resistant Staphylococcus aureus

This study evaluates in vitro resistance development in MRSA to vancomycin, daptomycin, and linezolid, identifying mutations and mechanisms associated with resistance.

Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

This study shows that subpopulations of stationary phase bacteria resist antimicrobial peptides through enhanced efflux and other mechanisms, and suggests combining tachyplesin with sertraline to combat resistance.

Evaluating the Genome and Resistome of Extensively Drug-Resistant Klebsiella pneumoniae using Native DNA and RNA Nanopore Sequencing

This study compares DNA and RNA nanopore sequencing for detecting drug resistance in XDR K. pneumoniae, finding RNA sequencing identifies more resistance genes and shows strong correlation with qRT-PCR.