Author

Edwin Frank Ortega

University of California, San FranciscoORCID 0000-0002-3890-0413Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Kai R. TrepkaiD· 3 shared Peter James TurnbaughiD· 3 shared Vaibhav UpadhyayiD· 3 shared Cecilia A. NoeckeriD· 2 shared Christine Olson· 2 shared Margaret AlexanderiD· 2 shared Rachel R. RockiD· 2 shared Taylor M. HalseyiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMicrobiology

Kai R. TrepkaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintAug 1, 2026

Shifts in the human gut microbiome during cancer chemotherapy are diet-dependent

Kai R. Trepka, Erin L. Van Blarigan, Edwin Frank Ortega…·Peter James Turnbaugh

This study shows diet changes during cancer chemotherapy affect gut microbiome composition and diversity, with specific nutrients linked to microbial shifts and toxicity.

DOI 10.64898/2025.12.23.696294

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivPreprintMar 23, 2026

Female-enriched Eggerthella lenta drives neuroinflammation and IFN-γ via host receptor TLR2

Rachel R. Rock, Margaret Alexander, Cecilia A. Noecker…·Peter James Turnbaugh

The paper identifies a female-enriched gut bacterium, Eggerthella lenta, that drives neuroinflammation and IFN-γ via TLR2 in autoimmune disease models.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky

Molecular BiologybioRxivPreprintMar 24, 2025

Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury

Vaibhav Upadhyay, Edwin Frank Ortega, Luis A. Ramirez Hernandez…·Peter James Turnbaugh

This study shows gut bacteria produce lactate that increases lung epithelial mitochondrial activity and worsens acute lung injury.

DOI 10.1101/2025.03.24.645052

mousemetabolomics

𝕏 PostBluesky