Christopher M. Hammell

The paper identifies a developmental timer in C. elegans that coordinates microRNA transcription across tissues through a feedback loop between MYRF-1 and LIN-42.

The paper identifies MYRF-1 as a regulator of non-apoptotic linker cell death in C. elegans, showing its role in priming death through activation of pqn-41/polyQ.

The paper identifies 3' nucleotide asymmetry as a key factor in miRNA strand selection, showing its role in guiding the loading of the guide strand into miRISC in C. elegans and human cells.

The paper identifies FLYWCH transcription factors that regulate lin-42/Period autoregulation, controlling DTC migration in C. elegans gonad development.

This study identifies lin-67 as a heterochronic gene that negatively regulates lin-4, let-7, and alg-1, affecting developmental timing in C. elegans.

The paper investigates how NHR-67 and Groucho regulate the switch between proliferative and invasive states in C. elegans uterine cells.

This paper introduces a FLP-ON::TIR1 system for precise spatiotemporal protein degradation in C. elegans, showing it can drive efficient target protein degradation in specific cell types.

The paper shows that NHR-85 and NHR-23 heterodimers regulate lin-4 miRNA transcription pulses in C. elegans, similar to circadian clock mechanisms in mammals.

The paper introduces an engineered auxin analog and AtTIR1(F79G) pair to improve the specificity and efficacy of the auxin degradation system in C. elegans.

This paper identifies pqn-59 as a factor that antagonizes miRNA-mediated repression and promotes stress granule formation in C. elegans, contributing to regulatory bistability in developmental gene networks.

The paper shows that ubiquitination of Clr4SUV39H1 by Ubc4 promotes transcriptional silencing through phase separation and ncRNA regulation.

The paper identifies an epigenetic priming mechanism mediated by BLMP-1 that decompacts chromatin to regulate transcriptional output in response to nutrient sensing.

This paper improves the AID system in C. elegans for single-cell protein degradation using NAA and demonstrates its application in developmental studies.