Jeffrey C. Medley

3' Nucleotide Asymmetry Directs miRNA Strand Selection

The paper identifies 3' nucleotide asymmetry as a key factor in miRNA strand selection, showing its role in guiding the loading of the guide strand into miRISC in C. elegans and human cells.

In silico unwinding of Caenorhabditis elegans microRNA duplexes to evaluate thermodynamic end stabilities improves predictions of microRNA strand selection

The paper improves miRNA strand selection predictions by calculating thermodynamic stability of duplex ends using constrained RNA folding in C. elegans.

LIN-67 functionally interacts with heterochronic miRNAs and regulates developmental timing in Caenorhabditis elegans

This study identifies lin-67 as a heterochronic gene that negatively regulates lin-4, let-7, and alg-1, affecting developmental timing in C. elegans.

Single Nucleotide Substitutions Effectively Block Cas9 and Allow for Scarless Genome Editing in Caenorhabditis elegans

This study shows that single-nucleotide substitutions in the guide sequence block Cas9 activity in C. elegans, enabling efficient genome editing without additional blocking mutations.

APC/CFZR-1 Controls SAS-5 Levels to Regulate Centrosome Duplication in Caenorhabditis elegans

The paper shows that FZR-1 regulates centrosome duplication in C. elegans by controlling SAS-5 levels through the ubiquitin-proteasome system.