Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules
Robert C. Wells, Padma Akkapeddi, Darren Chan, David A. Joy, Arash Moshkforoush, Roni Chau, Johann Chow, Gerald Maxwell Cherf, Ellen Y. T. Chien, Allisa J. Clemens, Michelle E. Pizzo, Ahlam N. Qerqez, Tiffany M. Tran, Isabel A. Becerra, Jason C. Dugas, , Kylie S. Chew
This paper demonstrates that dual targeting of TfR and CD98hc enhances brain exposure of large molecules compared to single-target approaches.
Cell Reports · Jul 22, 2025Peer-reviewedNeuroscience