Author

Robert C. Wells

Denali Therapeutics (United States)ORCID 0000-0002-2713-2201Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

Allisa J. Clemens· 2 shared Christopher M. KothiD· 2 shared David Huynh· 2 shared Elysia Roche· 2 shared Jason C. DugasiD· 2 shared Johann ChowiD· 2 shared Joseph W. LewcockiD· 2 shared Kylie S. ChewiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Allisa J. Clemens

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules

Robert C. Wells, Padma Akkapeddi, Darren Chan, David A. Joy, Arash Moshkforoush, Roni Chau, Johann Chow, Gerald Maxwell Cherf, Ellen Y. T. Chien, Allisa J. Clemens, Michelle E. Pizzo, Ahlam N. Qerqez, Tiffany M. Tran, Isabel A. Becerra, Jason C. Dugas, , Kylie S. Chew

This paper demonstrates that dual targeting of TfR and CD98hc enhances brain exposure of large molecules compared to single-target approaches.

Cell Reports · Jul 22, 2025Peer-reviewedNeuroscience

Targeting Transferrin Receptor to Transport Antisense Oligonucleotides Across the Blood-Brain Barrier

Scarlett J. Barker, Mai B. Thayer, Chaeyoung Kim, David Tatarakis, Matthew J. Simon, Rebekah L. Dial, Lizanne Nilewski, Robert C. Wells, Yinhan Zhou, Megan E. Afetian, Alfred E. Chappell, Kylie S. Chew, Johann Chow, Allisa J. Clemens, Claire B. Discenza, , Sarah L. DeVos

This paper demonstrates that systemically delivered OTV, a TfR-binding molecule, effectively transports ASO across the BBB, achieving widespread and sustained knockdown of target genes in the CNS of mice and non-human primates.

bioRxiv · Apr 25, 2023 · PreprintNeuroscience