Author

Lucy D. Brennan

University of California, BerkeleyORCID 0000-0002-4019-6904Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1 Assay:long-read sequencing· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Gary H. KarpeniD· 3 shared Serafin U. ColmenaresiD· 2 shared Aaron F. StraightiD· 1 shared Aaron StreetsiD· 1 shared Annie MaslaniD· 1 shared Collin HickmanniD· 1 shared Hyeong-Ku Kim· 1 shared Je‐Kyung RyuiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiophysics

Gary H. KarpenORCID

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3 papers

Recent·Most cited

HP1a promotes chromatin liquidity and drives spontaneous heterochromatin compartmentalization

Lucy D. Brennan, Hyeong-Ku Kim, Serafin U. Colmenares, Tatum Ego, Je‐Kyung Ryu, Gary H. Karpen

This study shows HP1a promotes chromatin liquidity and drives spontaneous heterochromatin compartmentalization through interfacial tension modulation.

Nucleic Acids Research · Feb 24, 2026Peer-reviewedBiophysics

Expanding the HP1a-binding consensus and molecular grammar for heterochromatin assembly

Serafin U. Colmenares, Shingo Tsukamoto, Collin Hickmann, Lucy D. Brennan, Mohammad Khavani, Mohammad R. K. Mofrad, Gary H. Karpen

The paper identifies an expanded HP1a-binding motif, HACs, and shows their role in heterochromatin assembly through molecular interactions and simulations.

Nucleic Acids Research · Sep 25, 2025Peer-reviewedMolecular Biology

Mapping protein-DNA interactions with DiMeLo-seq

Annie Maslan, Nicolas Altemose, Jeremy Marcus, Reet Mishra, Lucy D. Brennan, Kousik Sundararajan, Gary H. Karpen, Aaron F. Straight, Aaron Streets

The paper introduces DiMeLo-seq, a method for mapping protein-DNA interactions using long-read sequencing, and provides a protocol and analysis tool.

Nature Protocols · Sep 5, 2024Peer-reviewedGenomics