Cell BiologybioRxivPreprint
Outside-in progression of heterochromatin replication and exclusion of CDC45 from the PCH domain in Drosophila
Collin Hickmann, Srigokul Upadhyayula, Gary H. Karpen
The paper uses FOC-Map to analyze heterochromatin replication in Drosophila, finding replication foci initially at the PCH domain boundary and later within low-HP1a regions, with CDC45 depletion from the domain.
DOI 10.64898/2026.08.13.744572