This study shows HP1a promotes chromatin liquidity and drives spontaneous heterochromatin compartmentalization through interfacial tension modulation.

Nucleic Acids Research · Feb 24, 2026Peer-reviewedBiophysics

MORC2 phosphorylation fine tunes its DNA compaction activity

Winnie Tan, J.-G. Park, Hariprasad Venugopal, Jieqiong Lou, Prabavi Shayana Dias, Pedro L. Baldoni, Kyoung-Wook Moon, Toby A. Dite, Christine R. Keenan, Alexandra D. Gurzau, Joonyoung Lee, Timothy M. Johanson, Andrew P. Leis, Jumana M. Yousef, Vineet Vaibhav, , Shabih Shakeel

This study characterizes MORC2 phosphorylation's role in DNA compaction and chromatin remodelling, showing it regulates ATP hydrolysis and DNA binding.

Nature Communications · Jul 1, 2025Peer-reviewedMolecular Biology

EZH1 Q571R-mediated chromatin compaction and its oncogenic potential in thyroid cancer

Hanbyeol Kim, Do‐Gyun Kim, Seongyun Ha, Jun-Young Jang, Francisca N. de Luna Vitorino, Joanna M. Gongora, Woochul Kim, Yoonji Oh, Gyeongsik Park, Hyeji Kang, Soo-Hyun Im, Chan Kwon Jung, Seon-Young Kim, Inkyung Jung, Jae‐Kyung Won, , Chul‐Hwan Lee

This study shows that the EZH1Q571R mutation enhances chromatin compaction and PRC2 activity, leading to repression of tumor suppressor genes in follicular thyroid cancer.

bioRxiv · May 6, 2025 · PreprintMolecular Biology

Requirement of cholesterol for calcium-dependent vesicle fusion by stabilizing synaptotagmin-1-induced membrane bending

Houda Yasmine Ali Moussa, Kyung Chul Shin, Janarthanan Ponraj, Soo Jin Kim, Je‐Kyung Ryu, Said A Mansour, Yongsoo Park

This study shows cholesterol is required for Ca2+-dependent vesicle fusion by stabilizing synaptotagmin-1-induced membrane bending.

bioRxiv · Feb 3, 2022 · PreprintNeuroscience