Lauren A. Vanderlinden

scLASER: a robust framework for simulating and detecting time-dependent single-cell dynamics in longitudinal studies

scLASER simulates and detects time-dependent cellular dynamics in longitudinal studies, showing higher sensitivity than traditional methods in rare cell types and non-linear patterns.

Differences in immune cell profiles around the time of islet autoimmunity seroconversion in children with and without type 1 diabetes

The paper examines immune cell profiles around islet autoimmunity seroconversion in children with and without type 1 diabetes, finding differences in immune cell ratios that may reflect immune maturation disruptions.

Genome-Wide Association Study and transcriptome analysis reveals a complex gene network that regulates opsin gene expression and cell fate determination in Drosophila R7 photoreceptor cells.

The paper identifies genetic factors influencing opsin expression and cell fate in Drosophila R7 photoreceptors through GWAS and transcriptome analysis.

Single-cell based integrative analysis of transcriptomics and genetics reveals robust associations and complexities for inflammatory diseases

This study integrates GWAS and scRNA-seq to identify genetically relevant cell states in inflammatory diseases, finding scDRS outperforms scGWAS in capturing disease-relevant cellular heterogeneity.

Power and precision: Evaluation and recommendations of quantitative trait analysis methods for RNA expression levels in the Hybrid Rat Diversity Panel

The paper evaluates quantitative trait analysis methods for RNA expression in the HRDP to assess power and precision in identifying genetic variants associated with complex traits.

Identification of genes involved in the differentiation of R7y and R7p photoreceptor cells in Drosophila

The paper identifies genes involved in R7 photoreceptor cell differentiation in Drosophila through genetic screens and analyzes their effects on Rh3 expression.