Author

George Emanuel

Howard Hughes Medical InstituteORCID 0000-0002-4033-3251Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jiang HeiD· 2 shared Abhishek MurtiiD· 1 shared Angela Oliveira PiscoiD· 1 shared Angela VasaturoiD· 1 shared Aris Taychameekiatchai· 1 shared Ashley ByrneiD· 1 shared Bin Wang· 1 shared Bing Yang· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

Jiang HeORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintMar 7, 2026

MERFISH 2.0, an ultra-sensitive single-cell spatial transcriptomics imaging chemistry across diverse tissue types

Lizhi He, Bin Wang, Timothy Wiggin…·Jiang He

MERFISH 2.0 improves transcript detection sensitivity in degraded and archival tissues, enhancing spatial transcriptomic analysis of human and mouse samples.

3 citations

humanmouse

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BioinformaticsLife Science AlliancePeer-reviewedDec 16, 2022

Concordance of MERFISH Spatial Transcriptomics with Bulk and Single-cell RNA Sequencing

Jonathan Liu, Vanessa Tran, Venkata N. P. Vemuri…·Norma F Neff

The paper compares MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing in mouse liver and kidney, finding MERFISH provides comparable results and robust cell type identification without needing integration with scRNA-seq atlases.

108 citationstop 2%

mousespatial transcriptomics

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Systems BiologyNature MethodsPeer-reviewedOct 30, 2017

High-throughput, image-based screening of genetic variant libraries

George Emanuel, Jeffrey R. Moffitt, Xiaowei Zhuang

The paper introduces a high-throughput screening method to identify genetic variants with desired phenotypes by imaging barcoded mutants in individual cells.

78 citations

proteomicsexperimental assay

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