Author

Aaron Wai Kit Tan

National University of SingaporeORCID 0000-0002-4046-7380Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:virus· 2 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

G. FibriansahiD· 2 shared Gavin Robert ScreatoniD· 2 shared Shee‐Mei LokiD· 2 shared Thiam‐Seng NgiD· 2 shared Bo ShuiD· 1 shared Donald Heng Rong TingiD· 1 shared James E. CroweiD· 1 shared Jian R. ShiiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiophysics

G. FibriansahORCID

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2 papers

Recent·Most cited

Dengue virus 2 lacking N153 glycosylation displayed enhanced recognition by neutralizing antibodies

G. Fibriansah, Thiam‐Seng Ng, Xin-Ni Lim, Joeshua W. S. Ng, Aaron Wai Kit Tan, Donald Heng Rong Ting, Gavin Robert Screaton, James E. Crowe, Sylvie Alonso, Shee‐Mei Lok

The paper shows a dengue virus mutant lacking N153 glycosylation is more susceptible to neutralizing antibodies, as evidenced by increased Fab occupancy and slower dissociation rates.

npj Viruses · Sep 28, 2026Peer-reviewedBiophysics

CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever

Bo Shu, Justin S. G. Ooi, Aaron Wai Kit Tan, Thiam‐Seng Ng, Wanwisa Dejnirattisai, Juthathip Mongkolsapaya, G. Fibriansah, Jian R. Shi, V.A. Kostyuchenko, Gavin Robert Screaton, Shee‐Mei Lok

This study determines the tetrameric and hexameric structures of secreted dengue NS1, revealing their quaternary organization and how antibody binding affects their stability.

Nature Communications · Nov 8, 2022Peer-reviewedMolecular Biology