Shee‐Mei Lok

The paper shows a dengue virus mutant lacking N153 glycosylation is more susceptible to neutralizing antibodies, as evidenced by increased Fab occupancy and slower dissociation rates.

TARDIS is a deep learning framework that rapidly and accurately segments membranes and filaments in electron microscopy data, enabling large-scale biophysical analysis.

This study determines the tetrameric and hexameric structures of secreted dengue NS1, revealing their quaternary organization and how antibody binding affects their stability.