CRISPR-based Live Imaging of Epigenetic Modification-Mediated Genome Reorganization
Ying Feng, Yao Wang, Yang Chen, Ardalan Naseri, Thoru Pederson, Jing Zheng, Xiao Xiao, Shaojie Zhang, Wei Xie, Hanhui Ma
The paper develops a CRISPR-based system to image epigenetic modification effects on genome organization in living cells and shows it induces genomic relocation and H3K9me3 decoration.
bioRxiv · Feb 18, 2020 · PreprintMolecular Biology