Wei Xie

This study identifies ZFP281 as a coordinator of DNMT3A/3B and TET1 to regulate DNA methylation and gene expression during pluripotent stem cell state transitions.

This study identifies NR5A2 as a key regulator linking zygotic genome activation to the first lineage segregation in early mouse development.

The paper shows that global DNA methylation inheritance and enhancer dememorization in zebrafish embryos protect embryonic gene programs by preventing ectopic gene activation.

The paper examines chromatin structural changes and epigenetic reprogramming during mouse and human embryonic development, showing domain segregation correlates with genetic and epigenetic changes.

The paper highlights a normalization issue in ChIC-based methods that distorts signal-to-noise ratios, leading to misleading results in open chromatin bias analysis.

This study uses EpiGo-KRAB to introduce H3K9me3 at specific loci and shows it forms heterochromatin-like domains without widespread gene repression.

The paper develops a CRISPR-based system to image epigenetic modification effects on genome organization in living cells and shows it induces genomic relocation and H3K9me3 decoration.

This study identifies L1 and B1 retrotransposons as key elements shaping the 3D chromatin structure through spatial compartmentalization in human and mouse cells.

The paper uses single cell triple-omics analysis to reveal how epigenetic changes drive germ layer specification in mouse embryos, showing distinct epigenetic priming and remodeling in different lineages.