Author

Yang Chen

Beijing National Research Center for Information Science and TechnologyORCID 0000-0002-1863-5544Unclaimed ORCID profile · follow to get notified of new preprints

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Yang Chen10 papers · Chinese Academy of Sciences

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:CITE-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:scATAC-seq· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Ardalan NaseriiD· 1 shared Hanhui MaiD· 1 shared Jing ZhengiD· 1 shared Lang ZengiD· 1 shared Michael Q. ZhangiD· 1 shared Minglei ShiiD· 1 shared Minping Qian· 1 shared Shaojie ZhangiD· 1 shared

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2020-2020 · peak 2/yr

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10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Ardalan NaseriORCID

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2 papers

Recent·Most cited

MarkovHC: Markov hierarchical clustering for the topological structure of high-dimensional single-cell omics data

Zhenyi Wang, Yanjie Zhong, Zhaofeng Ye, Lang Zeng, Yang Chen, Minglei Shi, Minping Qian, Michael Q. Zhang

MarkovHC is a clustering algorithm that identifies cell types, trajectories, and critical points in single-cell omics data by reconstructing a pseudo-energy landscape based on metastability theory.

bioRxiv · Nov 4, 2020 · PreprintBioinformatics

CRISPR-based Live Imaging of Epigenetic Modification-Mediated Genome Reorganization

Ying Feng, Yao Wang, Yang Chen, Ardalan Naseri, Thoru Pederson, Jing Zheng, Xiao Xiao, Shaojie Zhang, Wei Xie, Hanhui Ma

The paper develops a CRISPR-based system to image epigenetic modification effects on genome organization in living cells and shows it induces genomic relocation and H3K9me3 decoration.

bioRxiv · Feb 18, 2020 · PreprintMolecular Biology