Simultaneous Epigenetic Perturbation and Genome Imaging Reveal Distinct Roles of H3K9me3 in Chromatin Architecture and Transcription
Ying Feng, Yao Wang, Xiangnan Wang, Xiaohui He, Yang Chen, Ardalan Naseri, Thoru Pederson, Jing Zheng, Shaojie Zhang, Xiao Xiao, Wei Xie, Hanhui Ma
This study uses EpiGo-KRAB to introduce H3K9me3 at specific loci and shows it forms heterochromatin-like domains without widespread gene repression.
Genome biology · Dec 1, 2020Peer-reviewedMolecular Biology