Site-specific immunogenicity and anti-PD1 response in mismatch repair deficient lung adenocarcinoma models
Etna Abad, Ivan Zadra, Anastasia Krasko, Marc Subirana-Granés, Diana Reyes-Garau, Pablo Borredat, Lorenzo Pasquali, Jose F. Aramburu, Cristina López‐Rodríguez, Ana Janic
This study compares immunotherapy responses in subcutaneous and orthotopic dMMR LUAD models, finding that orthotopic models show better anti-PD1 response with increased immune infiltration and CD4+ memory T cells.
bioRxiv · Jan 13, 2025 · PreprintCancer Biology