Cristina López‐Rodríguez

The paper identifies distinct gene signatures in effector T cells from poorly perfused tumor regions, showing enhanced IFN response and reduced PD-1 expression.

This study compares immunotherapy responses in subcutaneous and orthotopic dMMR LUAD models, finding that orthotopic models show better anti-PD1 response with increased immune infiltration and CD4+ memory T cells.

The paper shows that Nav1.7 loss of function analgesia requires both mu and delta opioid receptors, and enkephalin upregulation alone is insufficient for analgesia.