Jakov Korzhenevich

This study uses scRNA-seq and immunophenotyping to analyze immune changes in RA patients on MTX, showing early restoration of naive T/B cells and reduced memory T cells, with plasmablasts as a potential biomarker.

The paper develops a multiplex phosphoflow assay to profile age- and immune cell-specific signaling activation in 18 subpopulations, revealing distinct patterns in healthy individuals aged 1-69 years.

This study creates a single-cell multiomics atlas of B cell development in prenatal and adult bone marrow and in vitro models, identifying novel cell subsets and molecular signatures.