Time-resolved immune dynamics in rheumatoid arthritis under Methotrexate therapy
Teresa Preglej, Anela Tosevska, Marie Brinkmann, Philipp Schatzlmaier, Franziska Schmidt, Jakov Korzhenevich, Elisabeth Simader, Daniela Sieghart, Philipp Hofer, Thomas Krausgruber, Lina Dobnikar, Christoph Bock, Thomas Karonitsch, Renate Kain, Hannes Stockinger, , Michael Markus Bonelli
This study uses scRNA-seq and immunophenotyping to analyze immune changes in RA patients on MTX, showing early restoration of naive T/B cells and reduced memory T cells, with plasmablasts as a potential biomarker.
Annals of the Rheumatic Diseases · Jun 11, 2026Peer-reviewedGenomics