Alyssa J. Miller

This paper develops a human airway organoid platform to expand and map the differentiation trajectories of pulmonary neuroendocrine cells.

The paper identifies a novel secretory-like cell type in the developing human lung that gives rise to pulmonary neuroendocrine cells and multiciliated cells.

The paper identifies R-SPONDIN2-expressing mesenchymal cells as a niche for lung bud tip progenitors using single-cell RNA sequencing and functional experiments.

The paper identifies SMAD signaling as a regulator of basal cell fate specification in the developing human lung using single-cell transcriptomics and organoid models.

This study induces and engrafts human pluripotent stem cell-derived lung bud tip progenitor-like cells in vitro and in vivo, showing their similarity to native lung tissue and multi-lineage potential.