Zhiwei Xiao

This paper introduces a statistical framework for disease classification using scRNA-seq data, achieving better interpretability and performance compared to existing methods.

The paper constructs a developmental cell atlas of the human esophagus and develops in vitro models that recapitulate esophageal architecture, revealing WNT2B's role in regulating basal progenitor self-renewal.

The paper compares mesenchymal cell development in mouse and human intestines using scRNA-seq, finding conserved cell types but differing lineage-defining genes.

This study develops iPSC-derived lung bud tip progenitor organoids that can be expanded and differentiated into airway or alveolar organoids, showing transcriptional similarity to in vivo progenitors.

The paper identifies a novel secretory-like cell type in the developing human lung that gives rise to pulmonary neuroendocrine cells and multiciliated cells.

This paper develops and evaluates [11C]26, a PET probe for imaging PDE7 in the brain, showing promising in vitro performance and moderate specific binding in nonhuman primates.