Renee F. C. Hein

This study identifies opposing roles for TGFbeta and BMP signaling in generating AT2-like cells from lung progenitors in vitro.

This study develops iPSC-derived lung bud tip progenitor organoids that can be expanded and differentiated into airway or alveolar organoids, showing transcriptional similarity to in vivo progenitors.

The paper identifies a novel secretory-like cell type in the developing human lung that gives rise to pulmonary neuroendocrine cells and multiciliated cells.

The paper identifies R-SPONDIN2-expressing mesenchymal cells as a niche for lung bud tip progenitors using single-cell RNA sequencing and functional experiments.

The paper identifies SMAD signaling as a regulator of basal cell fate specification in the developing human lung using single-cell transcriptomics and organoid models.