Author

Nicholas D. Gansemer

University of IowaORCID 0000-0002-4069-9683Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:plant (other)· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Brieanna M. Hilkin· 3 shared David Anthony StoltziD· 3 shared Joseph ZabneriD· 3 shared Mahmoud H. Abou AlaiwaiD· 3 shared Alejandro A. PezzuloiD· 2 shared Anthony J. FischeriD· 2 shared David Kyle MeyerholziD· 2 shared Kristin M. WhitworthiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

Brieanna M. Hilkin

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3 papers

Recent·Most cited

In Utero CFTR Modulation Alleviates Disease in G551D Cystic Fibrosis Pigs

Sarah E. Ernst, David Kyle Meyerholz, Melissa Samuel, Kristin M. Whitworth, Youssef Wahib Naguib, David S. Nakhla, Mahmoud H. Abou Alaiwa, Christoph O. Randak, Qian Dong, Lynda S. Ostedgaard, Tayyab Rehman, Brieanna M. Hilkin, Linda S. Powers, Mal R. Stroik, Nicholas D. Gansemer, , David Anthony Stoltz

This paper shows that in utero ivacaftor treatment rescues multiple organ defects in CFTR-G551D pigs, improving pancreatic, gallbladder, and vas deferens function.

bioRxiv · Jan 21, 2026 · PreprintPhysiology

Mucociliary Clearance is Impaired in Small Airways of Cystic Fibrosis Pigs

Carley G. Stewart, Brieanna M. Hilkin, Nicholas D. Gansemer, Ryan J. Adam, David Dick, John J. Sunderland, David Anthony Stoltz, Joseph Zabner, Mahmoud H. Abou Alaiwa

This study shows that mucociliary clearance is impaired in small airways of cystic fibrosis pigs, with impaired clearance exacerbated by purinergic agonist stimulation.

American Journal of Physiology-Lung Cellular and Molecular Physiology · Aug 6, 2024Peer-reviewedPhysiology

Development and Initial Characterization of Pigs with DNAI1 Mutations and Primary Ciliary Dyskinesia

Mahmoud H. Abou Alaiwa, Brieanna M. Hilkin, Margaret P. Price, Nicholas D. Gansemer, Michael R. Rector, Mal R. Stroik, Linda S. Powers, Kristin M. Whitworth, Melissa Samuel, Akansha Jain, Lynda S. Ostedgaard, Sarah E. Ernst, Winter Philibert, Linda D. Boyken, Thomas O. Moninger, , David Anthony Stoltz

This paper develops a PCD pig model with DNAI1 mutations and characterizes its respiratory and sinus disease features, showing similarities to human PCD.

bioRxiv · May 22, 2024 · PreprintPhysiology