Alejandro A. Pezzulo

This study defines a functional correction threshold for gene therapies in PCD by analyzing how mixed populations of mutant and wild-type ciliated cells affect mucociliary transport.

This paper shows that in utero ivacaftor treatment rescues multiple organ defects in CFTR-G551D pigs, improving pancreatic, gallbladder, and vas deferens function.

This study shows that acute malaria infection reduces the effectiveness of a low-dose Ebola vaccine by impairing antibody responses in lymph node macrophages, which can be mitigated with higher vaccine doses.

This study shows IL-13 protects airway epithelial cells from SARS-CoV-2 infection in vitro but worsens disease severity in mice through eicosanoid signaling.

This study identifies pulmonary complement activation in a mouse model of severe COVID-19, showing local complement production and its role in lung injury.

This paper develops a PCD pig model with DNAI1 mutations and characterizes its respiratory and sinus disease features, showing similarities to human PCD.

This study shows that lentiviral vector transduction of airway basal cells does not impair their differentiation or function, suggesting potential for long-term gene therapy in lung diseases.

The paper compares gene expression and function of airway cell types in small and large porcine airways, finding distinct transcriptomes and functional roles.

This study evaluates a bulk RNA-seq method using direct cell lysis without RNA extraction, showing it produces high-quality data comparable to traditional methods with lower costs.