Sarah E. Ernst

The paper examines subclonal complete loss of CDKN1B in prostate cancer, finding higher prevalence in African American individuals and associations with worse outcomes.

This paper shows that in utero ivacaftor treatment rescues multiple organ defects in CFTR-G551D pigs, improving pancreatic, gallbladder, and vas deferens function.

This study develops a ddPCR method to detect low-abundance TMPRSS2:ERG gene fusion transcripts in prostate cancer cells and evaluates potential initiators of these fusions.

This study identifies a bacterial pathway for androgen production, showing that gut and urinary bacteria can convert androstenedione to epitestosterone and testosterone, which promote prostate cancer growth.

This paper develops a PCD pig model with DNAI1 mutations and characterizes its respiratory and sinus disease features, showing similarities to human PCD.

The paper presents an analysis pipeline for integrating data from multiple hypervariable regions in 16S rRNA sequencing and applies it to a clinical cohort.