Alain Ndayisaba

This study shows that tRNA-derived fragments (tRFs) accumulate in aging mouse brains and are elevated in human neurodegenerative conditions, suggesting a role in neurodegeneration.

This study develops a human brain tissue model (miBrain) to show that APOE4 astrocytes with cholesterol dysregulation promote α-synuclein pathology through endolysosomal dysfunction.

This study shows that AAGGG repeat expansions cause synaptic defects in CANVAS neurons independently of RFC1, with phenotypes corrected by repeat deletion.

This paper develops an iPSC platform to rapidly generate alpha-synuclein inclusions and investigates their formation, subtypes, and molecular interactions.