Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells
Bin Sun, Jing Guo, Dong Yang, Qiancheng Hu, Haiyan Ma, Panwen Tian, Nan Liu, Longbao Lv, Lanzhen Yan, Hao Ding, Maoyong Fu, Hongfeng Gou, Dan Cao, Dan Liu, Peng Shi, , Xudong Zhao
This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.
Oncogene · Apr 18, 2026Peer-reviewedImmunology