Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells
Bin Sun, Jing Guo, Dong Yang…·Xudong Zhao
This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.
Author
Sichuan UniversityORCID 0000-0003-2755-7258Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Bin Sun, Jing Guo, Dong Yang…·Xudong Zhao
This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.
Ruihan Zhou, Chaoxin Xiao, Ping Zhou…·Chengjian Zhao
The paper introduces NICHE, a multi-omics framework to analyze immune niches in lung cancer, revealing fibroblasts with dual roles in tissue repair and immunosuppression.
Hao Kong, Xiangji Wu, Qingxin Yang…·Hong Jiang
The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.