Shashank Gandhi

A robust human airway organoid platform enables scalable expansion and trajectory mapping of pulmonary neuroendocrine cells

This paper develops a human airway organoid platform to expand and map the differentiation trajectories of pulmonary neuroendocrine cells.

The Wnt1-Cre2 transgene causes aberrant recombination in non-neural crest cell types

This paper characterizes aberrant recombination in non-neural crest cell types using the Wnt1-Cre2 driver, showing ectopic activation in gut endoderm and intestinal epithelium.

RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification

The paper identifies Elavl1/HuR as essential for maintaining cranial neural crest specification by stabilizing Draxin mRNA.

Evaluation and rational design of guide RNAs for efficient CRISPR/Cas9-mediated mutagenesis in Ciona

The paper evaluates and designs efficient CRISPR/Cas9 guide RNAs for mutagenesis in Ciona, identifying sequence correlates of activity and introducing a cloning-free delivery method.