Marianne E. Bronner-Fraser

The paper uses lineage tracing to show that fate restriction in mouse embryos and stem cell-derived models is asynchronous and not solely determined by cell identity.

This paper introduces an automated LSCI platform for non-invasive, longitudinal imaging of chick embryo heart and vasculature, revealing breed and shell type variability in early development.

The paper identifies ependymomas as originating from the pre-neural crest/roof plate lineage using single-cell transcriptomics and lineage tracing.

The paper identifies core microRNAs involved in neural crest delamination and condensation during trigeminal ganglion formation in chick embryos and shows their role in promoting MET and neuronal differentiation.

The paper investigates how HIF1A-mediated pathways enhance euploid cell survival in chromosomally mosaic embryos by modulating hypoxia signaling and reducing aneuploidy.

The paper identifies two lineage-committed progenitors in the developing brain that generate forebrain/midbrain and hindbrain regions, and demonstrates their distinct chromatin landscapes and differentiation potential.

This study uses LSCI and DNN models to attempt early sex identification of chick embryos but finds insufficient accuracy for practical use.

The paper identifies a gene regulatory subcircuit in zebrafish cardiac neural crest cells that is reactivated during heart regeneration.

This paper uses laser speckle imaging to monitor chick embryo heart rate and blood flow in response to nifedipine and amlodipine, showing drug-specific effects on cardiovascular parameters.

This study shows that ablation of the right cardiac neural crest in chick embryos causes more severe and varied congenital heart defects compared to left ablation.

The paper demonstrates non-invasive laser speckle imaging for visualizing blood vessels in avian eggs and monitoring embryonic development with machine learning.

This study generates a zebrafish model of neurofibromatosis by inducible knockout of nf2a/b, revealing tumor development similar to human NF-2.

The paper shows retinoic acid signaling is coupled to hindbrain segmentation in sea lamprey, suggesting this is a conserved vertebrate feature.

The paper uses single-cell transcriptomics and lineage tracing in avian embryos to show that sacral neural crest cells contribute to specific neurons, glia, and mesenchymal cells in the post-umbilical gut.

The paper identifies enhancer regions regulating SMPD3 expression in neural crest cells during EMT and shows SoxE transcription factors control this expression.

This study shows that Fgf10 mutants in newts can regenerate near-normal hindlimbs despite severe developmental defects.

The paper identifies nSMase2 as a critical regulator of developmental EMT by inducing endocytosis to activate Wnt and BMP signaling during neural crest migration.

The paper investigates the evolutionary origins of myoblast fusion mechanisms in chordates, identifying the emergence of Myomaker and Myomixer and their roles in muscle development across species.

The paper identifies Elavl1/HuR as essential for maintaining cranial neural crest specification by stabilizing Draxin mRNA.

The paper uses single-cell RNA-seq to show that neural crest lineage segregation from the neural plate border occurs at early neurulation, not gastrulation.

This study shows that the piRNA pathway, via Piwil1, regulates epithelial-to-mesenchymal transition in chick neural crest cells by controlling Sox2 expression.

This study shows HIF-2α regulates neural crest stemness and development, with implications for neuroblastoma.

The paper shows that post-embryonic zebrafish enteric neurogenesis occurs from Schwann cell precursors, not resident cells, and is enhanced by prucalopride.

This study analyzes the neural crest gene regulatory network in sea lampreys to identify conserved and unique elements across vertebrates.

The paper identifies a conserved regulatory program driving lateral plate mesoderm emergence across chordates using zebrafish and comparative analysis.

This study maps Hox gene expression in the sea lamprey head to understand the evolution of the Hox-code in vertebrates, finding both similarities and differences with gnathostomes.

The paper identifies miR-203's role in neural crest epithelial-to-mesenchymal transition through epigenetic regulation, showing its interaction with Phf12 and Snail2 and its repression by DNMT3B.

This paper develops a method to maintain trunk neural crest cells as crestospheres in vitro and shows they retain stem-like properties and express trunk-specific markers.

This study shows Draxin regulates basement membrane remodeling during cranial neural crest EMT by controlling laminin expression stages and is mediated by Snail2.