Raphaël Margueron

This study identifies FANCM-RMI1/2 as a driver of PARP inhibitor sensitivity in BRCA2-deficient cells, revealing distinct adaptation mechanisms between BRCA1 and BRCA2 loss.

This study shows ULTRAPETALA1 modulates PRC2 activity and enhances H3K27me3 deposition in Arabidopsis, revealing a bivalent trxG/PcG factor mechanism for chromatin regulation.

The paper identifies a plant-specific PRC2 variant, PRC2.3, which uses ULTRAPETALA1 to target nucleosomes and deposit H3K27me3 at developmental genes.

The paper uses multi-omics analysis to compare malignant and normal uveal melanocytes, identifying genomic instability and a BAP1 promoter deletion as key features of uveal melanoma.

The paper identifies PRC2 cofactors that mediate small RNA recruitment to repress transposable elements in Paramecium.

This study identifies EZHIP as a novel cofactor of PRC2 that limits its activity in germ cells, leading to altered H3K27me2/3 deposition and impaired fertility in female mice.

The paper identifies BAP1 as a general transcriptional co-activator through CRISPR/Cas9-generated isogenic cell lines and shows it functions independently of the Polycomb machinery.