Tilman Borggrefe

The paper investigates RBPJ-DNA binding kinetics and cofactor interactions, finding that kinetic stability, not thermodynamic, governs target site specificity and that mutations affect both association and dissociation rates.

The paper identifies genomic features associated with Notch responsiveness by analyzing RBPJ binding dynamics and develops a machine learning approach to predict Notch responsiveness in different cellular contexts.

This study identifies HMG20A as a key regulator of head and heart development by modulating transcription programs in neural crest cells and cardiomyocytes through its association with the H2A.Z/PWWP2A/NuRD complex.

This study uses a Drosophila Su(H) model to show that AOS-linked RBPJ variants cause developmental defects by sequestering Notch cofactors, leading to dysregulated target gene expression.

This study shows that SPEN is essential for Xist upregulation during X chromosome inactivation initiation in female mouse ESCs by silencing Tsix.