Teodora Filipovska

This study compares ATAC-seq-based estimates of transcription factor activity with multiplexed reporter assays across perturbations, finding overlap but also discrepancies in their sensitivity to different TF types.

The paper systematically optimizes transcriptional reporters for 86 transcription factors and identifies 60 highly sensitive and specific reporters.

This study shows enhancers recruit cohesin to form chromatin domains, engage CTCF sites, and activate distant genes, with transcription factors and mediator required for all distances but cohesin specifically for long-range activation.