Author
MRC Laboratory of Molecular BiologyORCID 0000-0002-9904-9423Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Aditi Kaushik, Alba Ayats-Fraile, Vanessa Viera…·Madhusudhan Srinivasan
This study shows DNA catenation is essential for sister chromatid cohesion in budding yeast and metazoan chromosomes, as it provides force resistance necessary for accurate chromosome segregation.
Hon Wing Liu, Florian Roisné-Hamelin, Michael Taschner…·Stephan Gruber
The paper shows that SMC hinge domains selectively allow ssDNA to bypass obstacles during DNA loop extrusion, revealing a conserved mechanism across SMC complexes.
Madhusudhan Srinivasan, Naomi J Petela, Johanna C. Scheinost…·Kim Nasmyth
This study shows Scc2/4 maintains cohesin on chromosomes during G1 by blocking a Wapl-independent release mechanism, but is unnecessary during S phase for establishing cohesion.
Madhusudhan Srinivasan, Johanna C. Scheinost, Naomi J Petela…·Kim Nasmyth
The paper investigates how cohesin organizes DNA through both topological and non-topological mechanisms, showing that hinge domain mutations affect DNA entrapment and loading.