Author

Hendrik Luesch

University of FloridaORCID 0000-0002-4091-7492Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Amy Madeleine Kempf· 1 shared Anke WerneriD· 1 shared Chenglong LiiD· 1 shared Chi-Yuan Liu· 1 shared Daoyun Ding· 1 shared Eva Böttcher‐FriebertshäuseriD· 1 shared Gustavo de Miranda SeabraiD· 1 shared Heike Hofmann-Winkler· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

Amy Madeleine Kempf

Mutual co-authors in cluster

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2 papers

Recent·Most cited

MGMG: Cell Morphology-Guided Molecule Generation for Drug Discovery

Qiaosi Tang, Daoyun Ding, Xiaoyong Yuan, Gustavo de Miranda Seabra, Peter Ramdhan, Chi-Yuan Liu, My T. Thai, Chenglong Li, Hendrik Luesch, Yanjun Li

MGMG generates bioactivity-aware molecules using cell morphology and textual descriptions without target information, achieving comparable binding affinities to reference compounds.

bioRxiv · Jul 11, 2025 · PreprintBioinformatics

Proteolytic processing of the Marburg virus glycoprotein depends on Sec616β and is required for cell entry

Katharina E. Decker, Anke Werner, Markus Hoffmann, Heike Hofmann-Winkler, Qi-Yin Chen, Lu Zhang, Pamela Stomberg, Sabine Gärtner, Amy Madeleine Kempf, Inga Nehlmeier, Hendrik Luesch, Torsten Steinmetzer, Eva Böttcher‐Friebertshäuser, Nabil Georges Seidah, Stefan Pöhlmann, Michael Winkler

This paper identifies Sec61β as essential for proteolytic processing and cell entry of Marburg virus glycoprotein, unlike Ebola virus, and suggests Sec61 as a therapeutic target.

bioRxiv · Jun 26, 2025 · PreprintMicrobiology