Author

Linna Peng

GenentechORCID 0000-0002-4094-8002Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Abbas NaziriD· 2 shared Aviv RegeviD· 2 shared Hanchen WangiD· 2 shared Lisa M. McGinnisiD· 2 shared Aixia SongiD· 1 shared Ana Carolina LeoteiD· 1 shared Avtar SinghiD· 1 shared Bence DánieliD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Abbas NazirORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Spatiotemporal profiling reveals the role of inflammatory niche in driving prostate cancer

Abbas Nazir, Hanchen Wang, Ziyu Lu, Jeffrey Lau, Frank Peale, Rajiv Jesudason, Kelli A. Connolly, Žaneta Andrusivová, Julia Lau, Sarah Gierke, Linna Peng, Sara Chan, Jian Jiang, Sandra Rost, Eric Lubeck, , Aviv Regev

This study uses single-cell and spatial profiling to show that inflammatory signals from macrophages and fibroblasts drive CD8 T cell exhaustion and resistance to immune checkpoint blockade in prostate cancer.

bioRxiv · Apr 22, 2026 · PreprintCancer Biology

SpatialAgent: An Autonomous AI Agent for Spatial Biology

Hanchen Wang, Yichun He, Paula Pinto Coelho, Matthew Bucci, Abbas Nazir, Bob Chen, Linh T. Trinh, Serena Zhang, Ziyu Lu, Kexin Huang, Vineethkrishna Chandrasekar, Douglas C. Chung, Minsheng Hao, Ana Carolina Leote, Yong‐Ju Lee, , Aviv Regev

SpatialAgent integrates large language models with dynamic tool retrieval, multimodal interpretation, and claim verification to automate end-to-end spatial biology workflows from gene-panel design to tissue annotation and hypothesis generation.

bioRxiv · Apr 3, 2025 · PreprintBioinformatics

H3K4 di- and trimethylation modulate the stability of RNA polymerase II pausing

Shibin Hu, Aixia Song, Linna Peng, Nan Tang, Zhibin Qiao, Zhenning Wang, Fei Chen

This study shows that H3K4me3 dynamics regulate RNA polymerase II pausing through interactions with the INTAC termination complex and Pol II elongation.

bioRxiv · Nov 28, 2022 · PreprintMolecular Biology