Fei Chen

This study shows mechanical confinement drives monocyte-to-macrophage differentiation via a mechanoepigenetic pathway involving KDM6B and H3K27me3 demethylation.

This study shows that H3K79 methylation and H3K36 tri-methylation work together to control gene expression and neural cell fate in pluripotent stem cells.

This study identifies tissue-resident skeletal muscle macrophages that support muscle recovery from viral pneumonia in aging mice, with Mertk playing a key role.

This study identifies DSS1 as an essential subunit of the INTAC complex, showing its role in stabilizing INTAC and its impact on transcriptional regulation.

The paper identifies that BET inhibitor efficacy depends on the INTAC complex's auxiliary module, which interacts with the RACK7/ZMYND8-KDM5C complex to remove H3K4 methylation, thereby restoring sensitivity to BET inhibitors through WDR5 degradation.

The paper determines the structure of the PEC-INTAC complex and shows how INTAC facilitates RNA cleavage and CTD dephosphorylation during transcription termination.

This study shows that H3K4me3 dynamics regulate RNA polymerase II pausing through interactions with the INTAC termination complex and Pol II elongation.

The paper identifies RPAP2 as a gatekeeper that prevents preinitiation complex assembly by blocking Pol II-TFIIF interaction, thereby regulating transcription initiation.