Timothy A. Sutton

This study identifies a MEF2C transcription factor network that regulates endothelial cell proliferation in diabetic kidney disease and shows that SGLT2i treatment can reverse its dysregulation.

The paper defines the chromatin landscape of healthy and injured kidney cells using multi-omics data, identifying regulatory elements and transcription factor networks involved in injury response.

The paper creates a high-resolution cellular atlas of healthy and injured kidney cell states and niches using single-cell and spatial technologies, identifying molecular signatures and pathways related to kidney injury.

The paper identifies altered protein translation and carboxylic acid catabolism in diabetic kidney disease using human and mouse models.

The paper integrates spatial transcriptomics and single cell sequencing to identify immune and epithelial cell cross-talk patterns in acute kidney injury models.