This study uses multimodal neuroimaging to compare functional connectivity and tissue microstructure in two rat TBI models, finding distinct neuroadaptive differences.

Neurotrauma Reports · Sep 17, 2025Peer-reviewedNeuroscience

Improved Injury Detection Through Harmonizing Multi-Site Neuroimaging Data after Experimental TBI: A Translational Outcomes Project in NeuroTrauma (TOP-NT) Consortium Study

Gregory Kislik, R. Fox, Alexandru V. Korotcov, Jinyuan Zhou, Marcelo Febo, Babak Moghadas, Adnan Bibic, Yunfan Zou, Jieru Wan, Raymond C. Koehler, Tolulope Adebayo, Mark P. Burns, Joseph T. McCabe, Kevin Wang, John Russell Huie, , the TOP-NT Investigators

The paper evaluates NeuroCombat's effectiveness in harmonizing multi-site neuroimaging data from TBI rat models, showing improved statistical power and effect size after outlier removal and global sham population harmonization.

Frontiers in Neurology · Aug 20, 2025Peer-reviewedNeuroscience

Sleep Disruption in a Mouse Model of Chronic Traumatic Brain Injury

Andrew R. Morris, Erwin Kristobal Gudenschwager Basso, Miguel A. Gutierrez‐Monreal, Rawad Daniel Arja, Firas H. Kobeissy, Christopher Janus, Kevin Wang, Jiepei Zhu, Andrew C. Liu

This study develops a chronic TBI mouse model and finds that TBI leads to lifelong sleep/wake disturbances, circadian disruptions, and neuropathology.

Neurotrauma Reports · Jan 1, 2024Peer-reviewedNeuroscience

Translating from mice to humans: using preclinical blood-based biomarkers for the prognosis and treatment of traumatic brain injury

Ilaria Lisi, Federico Moro, Edoardo Mazzone, Niklas Marklund, Francesca Pischiutta, Firas H. Kobeissy, Xiang Mao, Frances Corrigan, Adel E Helmy, Fatima Ali Nasrallah, Valentina Di Pietro, Laura Benjamin Ngwenya, Luis Valmor Portela, Bridgette D. Semple, Douglas H. Smith, , the InTBIR Fundamental & Translational Working Group

This study reviews preclinical blood biomarkers for traumatic brain injury, finding that NfL and GFAP show promise for prognosis and pharmacodynamic studies.

bioRxiv · Dec 1, 2023 · PreprintNeuroscience

Compensatory functional connectome changes in a rat model of traumatic brain injury

Zhihui Yang, Tian Zhu, Marjory Pompilus, Yueqiang Fu, Jiepei Zhu, Kefren Arjona, Rawad Daniel Arja, Matteo M. Grudny, H. Daniel Plant, Prodip Bose, Kevin Wang, Marcelo Febo

This study examines functional connectome changes in a rat TBI model, finding increased connectivity and modularity in contralesional areas early post-injury, with partial recovery by day 30.

Brain Communications · Oct 1, 2021Peer-reviewedNeuroscience

Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study

Amber Nolan, Cathrine Petersen, Diego Iacono, Christine L. Mac Donald, Pratik Mukherjee, Andre J. W. van der Kouwe, Sonia Jain, Allison A. Stevens, Bram R. Diamond, Ruopeng Wang, Amy J. Markowitz, Bruce R. Fischl, Daniel P. Perl, Geoffrey T. Manley, Christopher Dirk Keene, , ROSS D. ZAFONTE

This study uses ex vivo diffusion MRI and histopathology to correlate tract disruptions with axonal injury in a TBI patient.

Journal of Neurotrauma · Jan 8, 2021Peer-reviewedNeuroscience

Screening of Tau Protein Kinase Inhibitors in a Tauopathy-relevant cell-based model of Tau Hyperphosphorylation and Oligomerization

Hamad Yadikar, Isabel Torres, Gabrielle Aiello, Milin Kurup, Zhihui Yang, Fan Yu Lin, Firas H. Kobeissy, Richard A. Yost, Kevin Wang

This study evaluates kinase inhibitors' effectiveness in reducing tau hyperphosphorylation and oligomerization in a cell-based tauopathy model using mouse and rat neuronal cultures.

PLoS ONE · Jul 21, 2020Peer-reviewedNeuroscience