Ron C. Anafi

The paper analyzes circadian gene expression amplitude across multiple human tissues and finds that global transcriptional amplitude varies by individual and tissue, but is not strongly correlated with core clock gene metrics.

This study compares circadian rhythms in photoprotected and photoexposed human skin, finding reduced rhythmic genes and advanced peak times in sun-exposed skin.

The paper introduces ORPHEUS, a method to quantify circadian desynchrony in single-cell data, finding reduced synchrony in AD-affected human brain excitatory neurons.

The paper identifies cell-type and disease-specific circadian gene expression changes in glial cells under amyloid pathology or aging in mice.

The paper estimates circadian phases in human brain cells using single-nucleus RNA sequencing and finds disrupted ribosomal rhythms in Alzheimer's patients.

This study shows that tanycyte Bmal1 deletion in female mice reduces weight gain on high-fat diet by altering hypothalamic neurogenesis, specifically affecting feeding-suppressing POMC neurons.

This study uses machine learning to predict sleep-related genes from genomic data and validates the NF-κB pathway's role in sleep duration in mice.

This paper introduces LTM, an in silico method to identify genetic influences on circadian clock function using gene expression data, and finds the cell cycle and extracellular matrix pathways are strongly associated with clock strength in human tissues.

This study identifies when circadian sleep emerges in Drosophila larvae and shows its role in enabling long-term memory.

This study identifies CBS-CRY1 binding as a regulatory mechanism linking circadian rhythms and metabolism, showing that CBS modulates CRY1 activity and vice versa.

The paper identifies robust circadian rhythms in human skin at the population level and develops single-sample biomarkers for circadian phase.

The paper identifies rhythmic gene expression across human tissues using computational methods and highlights implications for circadian medicine in cardiovascular disease.