Author

Winifred Trotman

University of PennsylvaniaORCID 0000-0002-4121-1889Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:imaging· 5 Approach:statistical model· 5 Research Focus:cell type annotation· 2 Research Focus:spatial domain detection· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Edward B. LeeiD· 5 shared David John IrwiniD· 4 shared Eunice P. ChungiD· 4 shared Paul A. YushkevichiD· 4 shared Ranjit Ittyerah· 4 shared Sydney LimiD· 4 shared Amanda E DenningiD· 3 shared Carlos de la Rosa‐PrietoiD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersNeuroscience

Edward B. LeeORCID

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5 papers

Recent·Most cited

Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies

Pulkit Khandelwal, Michael Tran Duong, Lisa M Levorse, Winifred Trotman, Alejandra Bahena, Sydney Lim, Amanda E Denning, Eunice P. Chung, Christopher A. Olm, Hamsanandini Radhakrishnan, Ranjit Ittyerah, Karthik Prabhakaran, Gabor Mizsei, Theresa Schuck, Sheina Emrani, , Paul A. Yushkevich

The paper examines subcortical and limbic volume associations with cortical thinning and neurodegenerative pathologies in postmortem brain MRI data from multiple disease groups.

Alzheimer s & Dementia · Jul 1, 2026Peer-reviewedNeuroscience

Microglial reactivity in the hippocampal CA2 is associated with advanced neuronal α-synucleinopathy

Esteban Luna, Katheryn A Q Cousins, Sheina Emrani, Sharon X. Xie, Winifred Trotman, Daniel A. Weintraub, Alice S. Chen‐Plotkin, Edward B. Lee, David John Irwin

This study examines the association between microglial reactivity and neuronal α-synucleinopathy in specific hippocampal subfields in Lewy body disease patients.

bioRxiv · Feb 11, 2026 · PreprintNeuroscience

Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II

HL Tucker, Bradley G. Karat, AT De Ruiter, Dana M. Parker, Sydney Lim, AE Denning, Ranjit Ittyerah, Lisa M Levorse, Winifred Trotman, Alejandra Bahena, Eunice P. Chung, Karthik Prabhakaran, Madigan L. Bedard, Daniel T. Ohm, Long Xie, , LEM Wisse

The paper characterizes hippocampal subfield border variability using postmortem MRI and histology, finding consistent subfield appearance/disappearance orders and no clear diagnosis-related differences.

bioRxiv · Nov 21, 2025 · PreprintNeuroscience

Developing an anatomically valid segmentation protocol for anterior regions of the medial temporal lobe for neurodegenerative diseases

Niyousha Sadeghpour, Sydney Lim, Anika Wuestefeld, Amanda E Denning, Ranjit Ittyerah, Winifred Trotman, Eunice P. Chung, Shokufeh Sadaghiani, Karthik Prabhakaran, Madigan L. Bedard, Daniel T. Ohm, Emilio Artacho‐Pérula, Maria Mercedes Iniguez de Onzono Martin, Mónica Muñoz, Francisco Javier Molina Romero, , Laura E.M. Wisse

The paper develops a segmentation protocol for anterior medial temporal lobe regions and integrates it into an automated approach to improve imaging biomarkers for neurodegenerative diseases.

Hippocampus · Jul 30, 2025Peer-reviewedNeuroscience

Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories

Anika Wuestefeld, Hannah Baumeister, Jenna N. Adams, Robin de Florès, Carl J. Hodgetts, Negar Mazloum‐Farzaghi, Rosanna K. Olsen, Vyash Puliyadi, Tammy Tran, Arnold Bakker, Kelsey L. Canada, Marshall Axel Dalton, Ana M. Daugherty, Renaud La Joie, Lei Wang, , Laura E.M. Wisse

This paper compares cytoarchitectonic delineations of medial temporal lobe subregions by four neuroanatomists, finding higher agreement in some areas and less in others.

Hippocampus · Feb 28, 2024Peer-reviewedNeuroscience