Author

Theresa Schuck

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:statistical model· 6 Assay:imaging· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Research Focus:spatial domain detection· 3 Research Focus:cell type annotation· 2 Research Focus:database / resource· 2

Frequent Co-Authors

David John IrwiniD· 4 shared Edward B. LeeiD· 4 shared Paul A. YushkevichiD· 4 shared Ranjit Ittyerah· 4 shared Sydney LimiD· 4 shared Anthony J. GriswoldiD· 3 shared Carlos de la Rosa‐PrietoiD· 3 shared Changiz GeulaiD· 3 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersNeuroscience

David John IrwinORCID

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Author profile →

7 papers

Recent·Most cited

Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies

Pulkit Khandelwal, Michael Tran Duong, Lisa M Levorse, Winifred Trotman, Alejandra Bahena, Sydney Lim, Amanda E Denning, Eunice P. Chung, Christopher A. Olm, Hamsanandini Radhakrishnan, Ranjit Ittyerah, Karthik Prabhakaran, Gabor Mizsei, Theresa Schuck, Sheina Emrani, , Paul A. Yushkevich

The paper examines subcortical and limbic volume associations with cortical thinning and neurodegenerative pathologies in postmortem brain MRI data from multiple disease groups.

Alzheimer s & Dementia · Jul 1, 2026Peer-reviewedNeuroscience

Enhanced Hi-C Capture Analysis reveals complex regulatory architecture at the PICALM-EED locus for Alzheimer Disease

Luciana Bertholim Nasciben, Liyong Wang, Wanying Xu, Aura María Ramírez, Sofia Moura, Leina Lu, Xiaoxiao Liu, Farid Rajabli, Katrina Celis, Marla Gearing, David Bennett, Sandra Weıntraub, Changiz Geula, Theresa Schuck, Karen Nuytemans, , Jeffery M. Vance

This study uses eHiCA to identify regulatory interactions at the PICALM-EED locus, showing distinct chromatin interactions for SNPs within a segregating haplotype.

bioRxiv · Feb 17, 2026 · PreprintGenomics

Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II

HL Tucker, Bradley G. Karat, AT De Ruiter, Dana M. Parker, Sydney Lim, AE Denning, Ranjit Ittyerah, Lisa M Levorse, Winifred Trotman, Alejandra Bahena, Eunice P. Chung, Karthik Prabhakaran, Madigan L. Bedard, Daniel T. Ohm, Long Xie, , LEM Wisse

The paper characterizes hippocampal subfield border variability using postmortem MRI and histology, finding consistent subfield appearance/disappearance orders and no clear diagnosis-related differences.

bioRxiv · Nov 21, 2025 · PreprintNeuroscience

Finding ancestry-specific chromatin architecture in Alzheimer's disease

Wanying Xu, Liyong Wang, Leina Lu, Xiaoxiao Liu, Farid Rajabli, Katrina Celis, Marla Gearing, David A. A Bennett, Margaret E. Flanagan, Sandra Weıntraub, Changiz Geula, Theresa Schuck, William K. Scott, Derek Michael Dykxhoorn, Anthony J. Griswold, , Jeffery M. Vance

The paper identifies ancestry-specific chromatin architecture differences in Alzheimer's Disease using Hi-C and ATAC-seq data from African and European ancestry individuals.

bioRxiv · Aug 19, 2025 · PreprintGenetics

Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories

Anika Wuestefeld, Hannah Baumeister, Jenna N. Adams, Robin de Florès, Carl J. Hodgetts, Negar Mazloum‐Farzaghi, Rosanna K. Olsen, Vyash Puliyadi, Tammy Tran, Arnold Bakker, Kelsey L. Canada, Marshall Axel Dalton, Ana M. Daugherty, Renaud La Joie, Lei Wang, , Laura E.M. Wisse

This paper compares cytoarchitectonic delineations of medial temporal lobe subregions by four neuroanatomists, finding higher agreement in some areas and less in others.

Hippocampus · Feb 28, 2024Peer-reviewedNeuroscience

Ancestry-related differences in chromatin accessibility and gene expression of APOE4 are associated with Alzheimer disease risk

Katrina Celis, Maria del Mar Muñiz Moreno, Farid Rajabli, Patrice L. Whitehead, Kara L. Hamilton‐Nelson, Derek Michael Dykxhoorn, Karen Nuytemans, Liyong Wang, Clifton L. Dalgard, Margaret E. Flanagan, Sandra Weıntraub, Changiz Geula, Marla Gearing, David Alan Bennett, Theresa Schuck, , Jeffery M. Vance

The paper shows that ELA-associated increased chromatin accessibility and expression of APOE4 in astrocytes contribute to higher AD risk in APOE4/4 carriers.

bioRxiv · Oct 27, 2022 · PreprintNeuroscience

3D Mapping of Neurofibrillary Tangle Burden in the Human Medial Temporal Lobe

Paul A. Yushkevich, Mónica Muñoz, Maria Mercedes Iniguez de Onzono Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Alex Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, , Ricardo Insausti

This study creates 3D maps of neurofibrillary tangle burden in the human medial temporal lobe using ex vivo MRI and dense histology, revealing variation along the anterior-posterior axis and widespread NFT distribution.

bioRxiv · Jan 15, 2021 · PreprintNeuroscience