Author

You Hu

University of FloridaORCID 0000-0002-4136-5941Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Organism:yeast· 1

Frequent Co-Authors

Andrew D. HansoniD· 2 shared Jorge D. García-GarcíaiD· 2 shared Steven D. BruneriD· 2 shared Bryan J. LeongiD· 1 shared Edmar R. Oliveira-FilhoiD· 1 shared Jaya JoshiiD· 1 shared Kristen Van GelderiD· 1 shared Qiang LiiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersSynthetic Biology

Andrew D. HansonORCID

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2 papers

Recent·Most cited

Directed evolution of aerotolerance in sulfide-dependent thiazole synthases

Kristen Van Gelder, Edmar R. Oliveira-Filho, Jorge D. García-García, You Hu, Steven D. Bruner, Andrew D. Hanson

This study improves the aerotolerance and activity of sulfide-dependent THI4 enzymes through directed evolution in yeast, identifying beneficial mutations that enhance their performance under aerobic conditions.

ACS Synthetic Biology · Mar 15, 2023Peer-reviewedSynthetic Biology

Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases

Jaya Joshi, Qiang Li, Jorge D. García-García, Bryan J. Leong, You Hu, Steven D. Bruner, Andrew D. Hanson

The paper identifies aerotolerant, multiple-turnover THI4 thiazole synthases in aerobic prokaryotes and shows they use cobalt as a cofactor instead of iron.

Biochemical Journal · Aug 19, 2021Peer-reviewedSynthetic Biology